User friendly real-time cell analysis (RTCA) software allows for real-time interfacing with all three cradles, and includes real-time data display and analysis functions. Real-Time, Label-Free Measurement of Natural Killer Cell Activity and Antibody-Dependent Cell- Me... Real-Time and Label-Free Monitoring of Virus-Mediated Cytopathogenicity, ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis, ACEA Biosciences to be Acquired by Agilent Technologies, Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award, Scientists Studying E. coli Biofilms Awarded xCELLigence Research Grant, Using Real-Time Potency Assay to Evaluate Cancer Immunotherapies, Live Cell Analysis Using xCELLigence Instruments, Viral Vaccine Development Gets Major Boost From xCELLigence RTCA, Characterizing Bacteriophage-Derived Enzymes that Degrade Staphylococcus Biofilms, Two Postdoctoral Fellows Researching Immunology and Cancer Biology Win ACEA Bioscience’s Travel Award, ACEA Biosciences’ Line of Real-Time Cell Analyzers Awarded “Premier Cell Analysis Instrument 2016”, ACEA Biosciences Research Grant Received by Tuberculosis Researcher at The Free University of Brussels, Using Cellular Impedance to Tackle Parasites, ACEA Biosciences, Inc. Building on the success of the impedance-only RTCA Cardio System, the new RTCA CardioECR system combines impedance and Multi Electrode Array (MEA) technology … The instrument operates in a standard CO2 cell culture incubator and the control unit is housed outside the incubator. The xCELLigence RTCA S16 instrument uses non invasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner.. Awards the 2015 iCELLigence Research Grant to Christian Owusu, Corporate Social Responsibility Statement, GPCR-, NHR-, and RTK-Mediated Cell Signaling, Cell Response Profiling: Small Molecule & siRNA. ACEA BioSciences, Inc ACEA Biosciences, Inc. has developed a label-free cell-based growth proliferation / inhibition assay which measures xenobiotic impacts in real-time using xCELLigence® electrical impedance monitoring system to visualize cell migration and morphology on the surface of electronic 96-well cell culture growth plates (E- plates). We use this instrument a lot. Otherwise the high sensitivity of the platform will play tricks on you. The xCELLigence DP is easy to use, provides the flexibility of monitoring cells in real-time and allows the assessment of multiple time points and dual functions in a single experiment, without the need to repeat tedious, conventional endpoint assays numerous times. ACEA Biosciences is a biotechnology company founded in 2002 and headquartered in San Diego, California. It is a simple setup with reproducible and reliable results. Good variety of plates- eg cytoview, migration can be used for lots of applications - cell viability, morphology ect. xCELLigence RTCA DP is very easy to use and easy to clean. Therefore, I would find it cool when there would be some kind of forum where users could discuss their problems and exchange tipps and tricks. This is one of the best and highly sensitive instrument for cell proliferation assays. Log data on conditions automatically so you can augment your cellular time course data with actual gas level data. The initial outlay for the instrument is high, but costs are covered in a short period. Lable-free and real-time analysis of cell growth and behavior made simple with xCELLIgence RTCA DP. Control optimal conditions all the way through data collection to enable time-course data collection without compromise. The xCELLigence RTCA S16 instrument uses biosensors to continously monitor live cell proliferation, morphology change, and attachment quality in a label-free and real-time manner. The machine is easy to use with a very well written manual and comes with a user friendly software. We are using the device to do proliferation and migration assay of different cancer cell lines. In all 10 out of 10 would recommend. Although, I don't like the software of the Xcelligence. Unlike end-point assays this continuous monitoring of cell growth/death gives a better understanding of the biological process. Home | Our Story | Applications | Products | Contact Us, Phone: (315) 387-3414 | Fax: (315) 387-3415, Dynamic O₂ Controller with Multiple Chambers. Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award 7/17/2018 Use the time and money you saved on the next project in your pipeline. The interface is wonderfully user friendly, and the data incredibly reproducible. Espacially that you can't safe the data analysis part and also that you always have to click newly what you want to see on the screen, when you open a new file. Can accomodate various cell lines which showed consistent results. Sometimes I find it difficult to interpret the results. To the Research Team of the Virology Laboratory at the Institute for Infectious Diseases at the University of Bern which shows successful implementation of the real-time cell analysis (RTCA) xCELLigence technology from ACEA Biosciences (now part of Agilent) to test acyclovir (ACV) susceptibility of Human Simplex Virus (HSV) clinical isolates. Our Cytocentric™ subchamber culture systems add unlimited range of oxygen levels, multiple simultaneous conditions and space/ gas efficiency, all inside your incubator. High reproducible Results. Cell invasion and migration measured in real-time. Additionally, the technical representative, whom the overseas distributor, sent is inexperienced and was unfamiliar with how to fix some of the problems we had. The supplier does not provide quotations for this particular product through SelectScience. Field Application Scientist (xCELLigence platform) ACEA Biosciences. What distinguishes the DP (dual purpose) model from our other xCELLigence instruments is its ability to additionally make kinetic measurements of cell invasion and migration (CIM) using an electronically integrated Boyden chamber (CIM-Plate® 16). However, the instrument needs to be regularly maintained and the cost of replacing broken parts can be quite prohibitive. It allows a complete scope on your process for short-term/ long-term experiments and overall cellular analysis. Bring in vivo oxygen levels to your in vitro assay so that only the best drug candidates make it through your first cellular analysis. RTCA software was used to determine CI values through the measured impedance recordings. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. A huge variety of cell-based assays, such as proliferation, adhesion, cytotoxicity, migration, morphological changes and more can be performed (for detailed information please visit our download section). Medline Industries Inc. transitions from paper-based data management to Abbott Informatics’... Peace of mind with Abbott Informatics cloud services, COVID-19 and Infectious Disease Webinar Series. Verry helpful for non invasive meassurement of proliferation, invation and migration assays. This video shows how you can obtain more information about your cells by acquiring data and advancing your cell-based research. ACEA is currently marketing the xCELLigence system directly to customers in North America and through distribution partnerships in the rest of the world. Apparently, it was his first time working on the machine when he came to us. Agilent acquired the xCELLigence biosensor technology through its purchase of cell analyzer manufacturer ACEA Biosciences last September, through a $250 million cash deal. Privately held ACEA, which is based in San Diego, has most recently developed a line of xCELLigence impedance-based, label-free, real-time cell analysis instruments that are used in immuno-oncology, pre-clinical drug … The xCELLigence system, continuously and non-invasively detects cell responses throughout an experiment. It also can be used for almost ANY cell type: unlike other systems it does not require intact monolayers. Take your weighing balance accuracy to the next level with automatic precision management and... On-demand webinar: NMR supersequences and multiple receivers in small molecule analysis, Increasing LC-MS accessibility for streamlined biotherapeutic analysis, Achieving data integrity through STARLIMS Scientific Data Management System, Achieving data integrity through STARLIMS standalone scientific data management system. The hybrid xCELLigence RTCA CardioECR system from ACEA Biosciences allows for both impedance readout and extracellular field potential (EFP) recordings in high-throughput format. Measure short-term and long-term cellular e˜ects. Application Area:Real time cell analysis of adherent cells. With a C-Chamber inside your incubator, you not only save on consumed gas but you double the number of conditions you can test simultaneously. Our lab is using the xCELLigence DP device pretty often. Over 1,000 of these instruments have been placed worldwide, leading to >700 publications in fields such as pre-clinical drug discovery and development, toxicity, safety … The highlight of this instrument is its small and does not take up the whole incubator space. The xCELLigence system uses specially designed microtiter plates containing interdigitated gold microelectrodes to noninvasively monitor the viability of cultured cells using electrical imp … We describe here the use of the xCELLigence system for label-free and real-time monitoring of cell … The IC50 function was also useful in surmising overall activity of novel anticancer drugs. Reproducibility of data is highly dependent on the user and his accurate pipetting skills. I have had excellent supporter backup regarding troubleshooting and tips to improve my assay. Provides real-time monitoring of cell culture, supplying data on cell proliferation, adhesion, differentiation, receptor-mediated responses, etc. Industry News Novel xCELLigence Study of Acinetobacter baumannii Biofilms Receives Award Cells were seeded at 3,000 cells/well in 200 μl of complete media (above) in E-plates (ACEA Biosciences, San Diego, California) and grown overnight while monitored with an xCELLigence SP system (ACEA Biosciences) which monitors cellular events in real time by measuring electrical impedance across inter-digitated gold micro-electrodes … Also, something like 70% of the well is electrode, making it incredibly sensitive to even small fluctuations. RTCA was invaluable in defining optimal seeding densities and drug concentration range and enabled us to detect instances of cell recovery which may otherwise have been overlooked. Reduce the time to clinic. Ideal for various types of Immunotherapy studies: It gives us a better understanding of how the cells are behaving and greater insight into our research. We had always effective and reproducible results throughout 0ur experiments. The ease of setting up the assay and watch the resulting graphs without having to do anything for days together is simply awesome. However, if reached, support is very competent and helpful. C-Chambers provide practical, controlled and isolated atmospheres for cell cultures; they may also be used for protected,uninterrupted transport for cells. Cells were seeded (10,000 cells/well) in E-plate 16 and allowed to adhere overnight before adding the cytotoxic agents or PGE 2. xCELLigence SP - Agilent technologies Basic tool with a huge impact for any cell based assay The RTCA SP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement. ", "An all-in-one autosampler customized for your needs". Firstly, cells were maintained at physiological oxygen levels during my research and therefore RTCA was chosen ahead of alternative cellular assays such as MTT due to a potential effect of varying oxygen on NADPH production which is needed for MTT reduction. The software could be improved, but all the data can be exported in Excel format, for further analyses. Organization: Tulane University School of Medicine, Application Area:Real time label free cellular analyses, Organization: Smith and Nephew Biotherapeutics, Application Area:Analyze the effect of drug substance on cell proliferation, Organization: Medical University of Vienna, Ear Nose and Throat Department, Application Area:Analyse cell responses of primary human nasal epithelial cells, Application Area:Proliferation and migration assays with cultures cells, Application Area:cell adhesion, proliferation and barrier function, Application Area:Proliferation; Migration Invasion assays, Application Area:Cell growth and behavior analysis upon chemicals and nanomaterial treatment, Organization: University Hospital Würzburg, Department of Neurosurgery, Application Area:Testing chemotherapeutics on glioblastoma cells, measuring proliferation and migration, Organization: National cancer Institute of Naples, Application Area:Cell migration, matrigel invasion, trans-endothelial and mesothelial migration, proliferation, Application Area:resistance to kinase inhibitors of cancer cells, immune cell mediated lysis assay, Application Area:titration of virus samples, Organization: Center for Cancer Immune Therapy, Organization: The University of Melbourne, Application Area:Investigate functional responses of cells to various stimuli, Application Area:cell growth response to novel anti-cancer chemotherapeutics, Application Area:Nanoparticle Drug Delivery, Organization: Hudson Institute of Medical Research, Organization: IFIB (Eberhard Karls Universität Tübingen), Application Area:Application: Cell growth and migrations, Application Area:We analyze the effect of potential cancer therapies on cancer cells. ACEA has a product line of 6 systems with different functionalities and throughputs, which are commercialized globally under the xCELLigence ® and iCELLigence TM brand. Furthermore, xCELLigence ® is scalable. However, recently everything runs smoothly. The instrument is placed in a standard CO2 cell culture incubator and is powered and controlled via a cable connected to the control unit (a laptop computer) housed outside the incubator. The... xCELLigence RTCA DP by Agilent Technologies. C-Chambers provide gas control of O2, CO2, and other gases to achieve physiological gas levels for cell culture being studied. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in … This system works really well also with cells that do not form monolayers, making it much more than just an ECIS system. Furthermore, RTCA detected not only drug-induced changes in cell number but also the kinetics of drug action. Aquinity² P10 – Ultra Pure water purification system, Atomic Absorption / Emission Spectroscopy, DS-11 Series Spectrophotometer / Fluorometer, Integrated Assay Prep / Analysis Workstations, Cancer immunotherapy: Agilent xCELLigence RTCA handbook, New Way to Monitor Virus-Mediated Cytopathogenicity, Identifying Endocrine Disruptors Using a Cell Panel-Based Real-Time Assay, Analysis of RNA Polymerase II Mutants Using the xCELLigence System, Investigating the Hallmarks of Cancer using xCELLigence Real-Time Cell Analysis, Cancer Immunotherapy Applications of xCELLigence® Real-Time Cell Analysis (RTCA) Systems, Using the xCELLigence System for Functional Genomics: Assessing Gene Function in Real Time, Culture and Monitoring of Animal Cells: Basic Techniques. The only downside of this instrument is the cost of the plates used. The continual real-time assessments are reproducible across experiments and have enabled me to look at processes I was unable to before with extreme ease. ACEA Biosciences Introduces "Fail it Fast" Assay Technology New xCELLigence RTCA CardioECR is the first platform for simultaneous measurement of Cardiomyocyte Contractility and Electrophysiology. resources with the revolutionary xCELLigence System from ACEA Biosciences. SAN DIEGO--(BUSINESS WIRE)--ACEA Biosciences and Memorial Sloan Kettering Cancer Center (MSK) have entered into a collaboration to evaluate a personalized ex vivo potency assay using cancer patients’ malignant pleural effusions and ACEA’s xCELLigence Real-Time Cell Analysis (RTCA) instrument to monitor destruction of the cancer cells by the patient’s own genetically … It could help us to solve various questions for different types of cells. The small reagent volumes required supports the economical use of limited reagents. Turn one incubator into two or more. Cells were monitored for one week. Most of our results are reproducable. Growth assays with xCELLigence. No variation in conditions when someone opens the incubator door. By Steven E. Kuehn, editor-in-chief. This acquisition brings together two pioneers in cellular function and metabolism measurements focused on real-time, live cell analyses. Pretty easy to use, love that you can get data while you're out of the lab. So easy to use. The S16 (single 16-well plate) model is the smallest within the xCELLigence instrument line. Perform real-time, label-free cellular assays to: Generate more physiologically relevant data. Program changes through a full range of O2 or CO2 levels in a dynamic atmosphere. ACEA Biosciences Launches xCELLigence RTCA Software Pro to Further Enhance Immuno-Oncology Experimental Design and Analysis 17 Oct 2018. Customer care (in Germany) sometimes is difficult to reach, especially when writing e-mail to our sales representative. Reduce variation and repeated experiments during cellular analysis by collecting data in real-time in an uninterrupted, yet controllable environment. This platform offered several advantages specific to my research needs. The company has just introduced the xCELLigence RTCA S16, which is the ideal entry level model for exploratory studies in cell biology. The three cradles of the DP instrument enable three separate electronic 16-well plates to be controlled and monitored in parallel or independently of one another, allowing maximal productivity for multiple users. ACEA is a pioneer in the development and commercialization of high-performance microelectronic systems for cell-based assays. The system is one of the best approaches used so far to test cell toxicity in cell-based assays. Acea Biosciences brings in an innovative technology for Real Time Kinetic Measurements. I would recommend it for cellular biology assays. Jun 2015 – Jan 2017 1 year 8 months. Good for short term response as well as long-term behaviour. The new iCELLigence System from ACEA Biosciences is a unique, impedance-based system for cell-based assays, allowing for label-free and real-time monitoring of cellular processes such as cell growth, proliferation, cytotoxicity, adhesion, morphological dynamics and modulation of barrier function. ACEA Biosciences is a company known for developing highly innovative products, which are used in academia, as well as the biotech and … I got after sales care for the first two years, which would be enough because the machine is not complicated and does not need much care except regular cleaning and common sense maintenance. By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional methods, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. CFX96 Touch™ Real-Time PCR Detection Sy... Stat Profile Prime Cell Culture Analyze... Fast Your inquiry will be delivered straight to the manufacturer, Secure We only pass your details on to trusted suppliers at your request, Save time Submit your details once and make multiple inquiries, "Easiest-to-use microplate reader by far - brilliant instrument! NEW YORK (GenomeWeb) – Agilent Technologies announced today that it has agreed to acquire ACEA Biosciences for $250 million in cash. Very user friendly. The xCELLigence ® RTCA System allows detection and differentiation among key hormone targets of EDCs such as estrogens, androgens and thyroid hormones. BioSpherix's Cytocentric SubChamber Culture System and ACEA Biosciences xCELLigence ® /iCELLigence ™ Real-Time Cellular Analysis Systems BRING IN VIVO TO YOUR IN VITRO ASSAY. Combine xCELLigence/ iCELLigence technology with our C-Chamber for more physiologically relevant cellular assay conditions. The immunotherapy module is designed to measure cytolysis of target tumor cells by immune effector cells and other molecules. 2.5. The xCELLigence® RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. In the past the computer sometimes was freezing for unknown reasons and then all data were lost. The results I obtained from my experiments on the RTCA DP system were interesting and as expected. On top of that, cells can potentially be re-used or analyzed on other platforms, as cells are not labelled with radioactive reagents or killed. All in all, this platform is highly recommendable for studying cellular toxicity. Latest: Shimadzu signs collaboration agreements to develop an 'Oxygenated compound analysis... Latest: Impact of STEC on the global food supply chain: Your questions answered, Latest: Thermo Fisher introduces new handheld XRF analyzer for elemental detection, SelectScience announces new CEO and investment partner Vespa Capital, Virtual Analytical Summit 2021: Full meeting agenda, BioTek announces new Cytation C10 Confocal Imaging Reader, Thermo Fisher introduces new handheld XRF analyzer for elemental detection. This simple to use instrument has revolutionized my experimental workflow. Overall the system was very user friendly and graphs generated were intuitive, informative and reproducible. And we are advertising the use of it, to other persons. Really easy to use and export experiments. Latest: Patient-derived human primary cancer cells, Latest: Virtual Analytical Summit 2021: Full meeting agenda. BioSpherix's C-Chambers are designed to fit right inside your existing incubator. The software is easy to use. xCELLigence RTCA Systems. xCELLigence ® Real Time Cell Analyzer (RTCA) allows the analysis of your cell culture in real time. The fact that you can monitor killing over multiple days (instead of the normal restriction of 6-24h in standard killing assays) makes it a must have. What distinguishes the DP (dual purpose) model from our other xCELLigence instruments is its ability to additionally make kinetic measurements of cell invasion and migration (CIM) using an electronically integrated Boyden chamber (CIM-Plate® 16). It is extremely easy to use and results are reproducible, as long as you keep your assay variables constant. There are over 800 customers worldwide, and over 350 peer-reviewed publications using the xCELLigence technology. The growth, proliferation, adhesion kinetics and ASFV-induced apoptosis on COS-1 cells were determined using an electrical impedance assay (RTCA-DP system, xCELLigence®, ACEA Biosciences, USA) (Spiegel, 2009). About us Follow us for regular updates on cell analysis technology news, events, and more. Once we had the problem, that the USB port of our device started to get rusty although we were using the device normally in our incubator. I have used this platform for testing cellular cytoxicity in immunotherapy. Program your own experiment profile and let our OxyCycler C42 control atmospheric changes for your cellular analysis. Rtca DP also continuously monitors indirect cell-to-cell interactions, cell invasion, and easy use. Cytotoxicity, cells adherence and proliferation assays etc model is the ideal entry model. Inside your existing incubator across experiments and overall cellular analysis let our OxyCycler C42 control atmospheric changes for your ''... Does not provide quotations for this particular product through SelectScience acea biosciences xcelligence use of limited reagents results produced with technique... 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Scientist ( xCELLigence platform ) ACEA Biosciences device is for sure worth the.., continuously and non-invasively detects cell responses throughout an experiment 2D models systems for cell-based assays new... Values through the measured impedance recordings reproducible across experiments and have enabled me to at... To look at processes i was unable to before with extreme ease new (! Not bad they may also be used for almost ANY cell type: unlike other systems it not. Xcelligence instrument line computer sometimes was freezing for unknown reasons and then all data lost...